Sildenafil Citrate Sildenafil Citrate is a prescription drug that was developed originally as a means to treat pulmonary arterial hypertension. What the manufacturers discovered was that it also seemed to be a suitable remedy for erectile dysfunction. Discovered and manufactured by the pharmaceutical company Pfizer under the brand name Viagra, this unanticipated turn of events obviously had an impact on the marketing side of their product. Through further study and testing this product became the number one treatment for erectile dysfunction in 1998. It works by reducing an enzyme [cGMP] found in the penis tissue that controls the blood flow. Since it hit the market a decade ago, sildenafil citrate has caused quite a stir. The discovery has even given way to an underground market for the drug, friends selling their prescriptions to friends! It also caused a flurry of activity among other drug manufacturers to develop competing brands. Tadalafil and Vardenafil are two competitors that are sold under the brand name Cialis and Levitra respectively. How does Sildenafil Citrate work? Sildenafil citrate (also known as Viagra) is a drug used to treat many Americans with various diseases such as, erectile dysfunction, altitude sickness, pulmonary hypertension and some athletes use [...]

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Generic Viagra side effects Generic Viagra gel is fast becoming a preferred method of combating the effects of erectile dysfunction. It is easy to take, and even comes in different flavours. However, like all major drugs, especially those that are used to treat sexual health problems, Generic Viagra in the gel form can have side effects. The side effects that Generic Viagra gel can produce are easily noticeable by both the doctor and the patient that he or she is treating. If you take the gel, and suffer from any of the side effects that are discussed in this article, then tell your doctor immediately. They should be able to offer you advice on how best to manage these side effects so that your health is not adversely affected. You may for example suffer from muscle pains. These can occur in the hand and feet areas of the body. They will not be especially acute in most cases, but if they persist, like most side effects; you should consult your doctor for advice on how best to manage them. They could persist to such an extent that they become chronic, so early identification and treatment are a must. If they [...]

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Sildenafil Citrate Gel For centuries, men have been struggling silently with the problem of erectile dysfunction. It has been a life threatening problem for millions of men, not because it can kill you directly, but because it can affect the quality of life of a man in quite drastic way. Consider the fact that a healthy sex life is important for most men. Even to a late age, men who are virile are much happier and more content than those who are not. In fact, being virile is seen as a major marker of happiness for men across the globe. This has been the case for a long time, but especially so in modern times, when media has promoted the idea that men who are able to lead healthy sex lives are better sexual partners and generally happier. Stress in the workplace and in life in general has been one of the major causes of erectile dysfunction among modern men. With harder working lives, and longer hours, many men have found it difficult to stop stress affecting them in a deep psychological sense. And this impact can directly affect their sex life. With all this going on, Sildenafil Citrate arrived [...]

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Erectile Dysfunction Erectile Disfunction (ED) is a common problem that affects nearly 140 million men worldwide, including 30 million men in America. The incidence of this problem increases with age. It is the failure to attain and sustain an erection that will allow for sexual satisfaction, and is classified as either mild, moderate, or severe erectile disfunction. It can have devastating effects on a man’s level of self confidence and destroy an intimate relationship. An erection begins with stimulation to both the senses and the mind. When a man becomes sexually stimulated, his brain sends a message down the nerves in the spinal cord to the penis. The many nerve endings that exist in the penis then release neurotransmitters to signal the penis to relax and fill with blood. As the penis fills with blood, it becomes stiff, erect, and enlarged. ED is a condition that can seriously impact the quality of life in a patient, their self esteem, and relationships with partners if left untreated. In over half of the men suffering from ED, this problem is caused by medical reasons such as diabetes, circulatory, neurological, or urological conditions. The other half experiencing ED difficulties have psychogenetic causes, or [...]

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An urologist in private practice in New York City, and a faculty member of New York University School of Medicine, Dr. Jed Kaminetsky specializes in treating sexual disfunction. Although treatments in the past always focused on sexual difficulties in the male population, he has now turned his focus on treating female disorders as well. He has been developing a drug that can enhance the ability to achieve orgasm and increase the level of sexual arousal in women. He developed two creams that are currently undergoing testing and have shown promising results. One of these creams contains sildenafil citrate, and when applied to the labia and clitoris, it resulted in better lubrication, increased arousal and more sexual pleasure. By increasing blood flow to the sexual organs, the cream increased genital sensation and assisted in the achievement of orgasm in women. A study on the effectiveness of this cream was conducted on 27 women volunteers who reported results in achieving orgasm that ranged from disappointing to explosive. Preliminary studies have been conducted on sildenafil cream as a treatment for postmenopausal women. Reduced hormone levels in older women cause subtle changes in the genital tissues. Some of the symptoms of menopause that inhibit [...]

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Anal fissures are linear ulcers in the anal canal, and can be very painful following defecation. A tear in the lower bowel that is resistant to healing typically causes fissures and this often leads to rectal bleeding. Typical treatments include surgery to reduce anal pressure or drug treatments to temporarily reduce pressure on the sphincter muscle and allow the ulcer to heal. As surgery may result in permanent sphincter disfunction causing fecal incontinence, drug treatment therapy is usually preferred. A number of topical solutions are used to treat anal fissures, including local, topical nitroglycerine, diltiazem, and locally injected botulinum toxin. The recommended treatment depends on the severity of the condition and the chronic nature of the problem. Sildenafil citrate is approved for use as a treatment for erectile disfunction as an inhibitor of phosphodiesterase 5, and its use results in increased nitric oxide induced smooth muscle relaxation. Thus, it has been suggested that it may be effective in reducing anal sphincter hyperactivity in patients with anal fissures. In a study involving 19 male and female patients with anal fissures, a topical cream containing 75 mg sildenafil was applied topically to the fissure. The study was conducted to test the results [...]

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Pulmonary Hypertension is commonly known as high blood pressure in the lungs, and is caused by diseases that narrow the blood vessels in the lungs. It causes shortness of breath, loss of energy, limits extertion, and causes decline and failure of the right ventricle in the heart. This disease is often fatal, since it causes additional strain on the heart and can lead to heart attacks. When the heart fails, the lungs fail to provide enough oxygen to the rest of the body. The method of treating this disease is to widen the blood vessels in the lungs and making it easier for the heart to pump blood through these vessels. One way to accomplish the widening of blood vessels is to inhale a mist called iloprost, which is a form of epoprostenol. However, its effects last for about 60 minutes so numerous inhalations are required throughout the day. Sildenafil was tested to learn if it could prolong the effects of iloprost. Another treatment for pulmonary hypertension is a continuous inhalation of nitric oxide gas, which also widens blood vessels in the lungs. In a study group, thirty patients with severe pulmonary hypertension volunteered to participate. The blood pressure and [...]

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Although Sildenafil citrate has been primarily used to treat erectile disfunction, this chemical also has health benefits for the heart. When Sildenafil was tested on mice, it had the effect of reversing the long term damage to the heart caused by chronic hypertension. The way that Sildenafil citrate works to maintain an erection is to expand genital blood vessels that carry the blood supply to the penis when aroused. In the same way, Sildenafil can benefit the heart to treat pulmonary hypertension. By dilating the blood vessels, Sildenafil causes a drop in blood pressure required to pump blood through the body. While conducting experiments on mice, researchers realized that sildenafil was able to stop the short term effects of hormonal stress and reverse the long term damage on the heart muscle. The effects of heart failure and cardiac hypertrophy were also improved by sildenafil in mouse experiments, although this effect was not tested on human subjects. To prove its effectiveness in humans, thirty five men and women participated in the John Hopkins study. In this test, volunteer participants took an injection of dobutamine, a chemical that increases the heart rate and contraction of the heart muscle. The heart rates of [...]

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Many products are currently available and sold online as dietary supplements that act as treatments for erectile disfunction, called “Blue Steel” or “Hero”, and the FDA has warned people not to buy them. They have not been approved for sale by the FDA, as their safety and effectiveness has not been proven through extensive testing. The chemicals they contain are similar to sildenafil, which is the active ingredient in Viagra, and they may pose serious health risks by affecting blood pressure levels. Blue Steel is sold in containers of 10 capsules or in blister packs holding 2 capsules. Hero is sold in blister packs of 2 capsules. Consumers may be misled into believing they are not harmful because these products are called all natural dietary supplements. However, caution must be taken if the patient has other medical conditions and is taking medications, such as nitrates, that interact negatively with these chemicals. Certain ingredients are not listed on the product, and these components could be potentially harmful to the unsuspecting consumer. Some prescription drugs contain nitrates that are used for the treatment of angina and heart failure. Nitrates relax a muscle in the blood vessels and allow the vessels to widen. [...]

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Before starting to take sildenafil, you should first consult with your doctor, as it may interfere with certain medications including vitamins, minerals, herbal products, and other prescription products. Some of these medications include nitrates, which are frequently prescribed to treat chest pain and angina, as sildenafil may cause a rapid and risky decrease in blood pressure and can lead to fainting, heart attack or stroke. If you have taken sildenafil, then you need to wait at least 24 hours for the drug to leave your system before nitrates can be used. Another medication that sildenafil interferes with are beta blockers, which are used to treat high blood pressure or prostate difficulties. Your doctor may recommend a lower dose of sildenafil. Protease inhibitors, that are used to treat HIV, may also be affected by sildenafil, so your doctor may limit the dose to a maximum of 25 mg every 48 hours. Approximately 15 percent of people taking sildenafil experience side effects. These side effects are usually mild and do not last more than a few hours. They include fever, headaches, flushing, muscle aches, nasal infection or stuffiness, vision problems, nosebleeds, sleeplessness, dizziness or light headedness, fainting, shortness of breath, stomach upset, [...]

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